Background and aim: Non-melanoma skin CANCERs (NMSC) are one of the most prevalent malignancies of the human. Although the morality rate is not high for these CANCERs, they may cause high morbility for the patients. In addition to the skin type, factors such as sun exposure, head and neck radiotherapy, inappropriate use of sunscreen and cultural changes may increase the incidence of these CANCERs. The objective of this study was to determine NMSC in Isfahan.Materials and Methods: We used data of the CANCER resistery center for performing this study and the incidence of NMSC per 100,000 populations was determined. Results: Overall 1681 cases were registered. The incidence of NMSC was calculated to be 10.67/100,000population. The most common site for BCC and SCC was middle face. Conclusion: NMSC incidence in Isfahan is lower than west countries although this incidence is 10.67/100,000in a year. It means that 5-6 thousand cases of NMSC occur in Iran each year. We can prevent its morbidity and mortality by early correct diagnosis.

The purpose of this study was comparing the stress of breast CANCER patients to that of healthy women. A sample of 65 breast CANCER patients were selected from "Imam-Khomeini CANCER Institute" (from summer to autumn of 2008). They were chosen from the available patients who were diagnosed with CANCER for less than two months. Variables such as marital status, economic status, age and education were taken into consideration in both the experimental and the control groups. Pickle's "life event" questionnaire (1971) was used to assess the stress in those groups. The data were analyzed using t-test. The results suggest that the stress in breast CANCER patients is significantly higher than others. Moreover, women who bereaved the loss of a relative, had unwanted pregnancy or experienced divorce had more stress.

Background: Polycystic OVARY syndrome (PCOS) is a heterogeneous, complex genetic disorder characterized by hyperandrogenemia, hyperinsulinemia, insulin resistance, and chronic anovulation. It is the most common endocrine disorder in women of reproductive age with an enigmatic pathophysiologic and molecular basis.  Obesity, hyperandrogenism, and infertility occur frequently in PCOS, which mostly have a genetic predisposition, and are features known to be associated with the development of breast CANCER risk.  Objective: In present study, frequency of PCOS in patients with premenopausal breast CANCER was compared with the frequency in women without breast CANCER.Materials and Methods: This is a case-control study, which compared PCOS frequency in 166 patients with premenopausal breast CANCER and 166 healthy controls with normal mammography in last 6 months.Results: Eleven patients (6.62%) in case group and 16 patients (9.63%) in control group had polycystic OVARY syndrome according to their questionnaire. The difference was not significant (p=0.645).Conclusion: There was no relationship between frequency of polycystic OVARY syndrome and breast CANCER in this study.  This might be due to the age of patients with breast CANCER in this study, which was mostly over 40.  It could be significant if the patients were chosen in lower age for showing more effect of genetic than environment.  The adjustment or matching of other risk factors could help to find the better results.

Introduction: AntiCANCER drugs insert their effect through inhibiting cell division or inducing apoptosis. Since cell proliferation is involved in folliculogenesis, one of the side effects of antiCANCER drugs is disturbing folliculogenesis. The aim of the present study is to investigate the effect of different doses of cyclophosphamide on folliculogenesis of adult female mice.Materials and Methods: In the present study, 40 female Balb/c mice, aging 6-8 weeks, were used. The mice in 3 experimental groups received 15 injections of cyclophosphamide as 0.3 mg/day, 0.6 mg/day, and 0.9 mg/day. The mice in control group only received the solvent. 15 days after last injection, the animals were sacrificed and ovarian specimens were processed for light microscopy. The serial sections were stained with HandE and studied with light microscope. The stereologic study was carried out using a computerized microscope and Motic software. The data were statistically analyzed using ANOVA.Results: Histological studies showed that the number of corpora lutea and follicles at different developmental phases decreased in experimental groups in comparison to control group. Histomorphometric and stereologic studies showed that the mean number of preantral follicles in an OVARY of control group was 142±8.6 and in experimental groups 1, 2 and 3 were 104±10.7, 76.6±8.5 and 42.4±6.5, respectively, which was significantly different from the control (p<0.05). The number of antral follicles in control group was 52.6±10.7 and in experimental groups (1, 2 and 3) were 22.5±5.4, 10±2.6 and 3.2±1.8, respectively, which was significantly different from control (p<0.05).Conclusion: According to the data obtained in the present study, the daily doses of 0.3-0.9 mg cyclophosphamide for two weeks, cause reduction in follicular number and ovulation in a dose dependent manner.